Olfactory dysfunction in LRRK2 G2019S mutation carriers
نویسندگان
چکیده
منابع مشابه
Olfactory identification in LRRK2 G2019S mutation carriers: a relevant marker?
OBJECTIVE Olfactory impairment is a potential marker for impending phenoconversion to Parkinson disease (PD) that may precede the development of disease by several years. Because of low specificity, it may be of greater predictive value in those with genetic mutations and its potential as a marker for developing LRRK2 PD should be evaluated. METHODS We examined olfactory identification in 126...
متن کاملGait alterations in healthy carriers of the LRRK2 G2019S mutation.
To test for an association between the LRRK2-G2019S mutation and gait, we studied 52 first-degree relatives of patients with Parkinson's disease (PD) who carry this mutation. An accelerometer quantified gait during usual-walking, fast-walking, and dual-tasking. Noncarriers (n = 27) and carriers (n = 25) were similar with respect to age, gender, height, and gait speed during all conditions. Duri...
متن کاملClinical heterogeneity of the LRRK2 G2019S mutation.
BACKGROUND Several pathogenic mutations have been reported in the leucine-rich repeat kinase 2 gene (LRRK2) that cause parkinsonism. The "common" LRRK2 G2019S kinase domain substitution has been reported to account for approximately 5% of familial and 1% of sporadic Parkinson disease. OBJECTIVE To observe the clinical heterogeneity presented by LRRK2 kinase mutation carriers. DESIGN, SETTIN...
متن کاملBRIEF COMMUNICATIONS Gait Alterations in Healthy Carriers of the LRRK2 G2019S Mutation
To test for an association between the LRRK2-G2019S mutation and gait, we studied 52 first-degree relatives of patients with Parkinson’s disease (PD) who carry this mutation. An accelerometer quantified gait during usualwalking, fast-walking, and dual-tasking. Noncarriers (n 1⁄4 27) and carriers (n1⁄4 25) were similar with respect to age, gender, height, and gait speed during all conditions. Du...
متن کاملDaT-SPECT assessment depicts dopamine depletion among asymptomatic G2019S LRRK2 mutation carriers
Identification of early changes in Dopamine-Transporter (DaT) SPECT imaging expected in the prodromal phase of Parkinson's disease (PD), are usually overlooked. Carriers of the G2019S LRRK2 mutation are known to be at high risk for developing PD, compared to non-carriers. In this work we aimed to study early changes in Dopamine uptake in non-manifesting PD carriers (NMC) of the G2019S LRRK2 mut...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurology
سال: 2011
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0b013e318227041c